You are not currently logged in.
Access your personal account or get JSTOR access through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Mutational Analysis of Developmental Control in Caulobacter crescentus
Mary Ann Osley and Austin Newton
Proceedings of the National Academy of Sciences of the United States of America
Vol. 74, No. 1 (Jan., 1977), pp. 124-128
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/66527
Page Count: 5
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
The relationship between the cell cycle and control of development has been studied by a genetic analysis of Caulobacter crescentus. The behavior of conditional cell division mutants showed that cell cycle events, such as DNA replication and cell division, are organized into a dependent pathway(s), i.e., later steps cannot proceed until earlier ones are completed. The ability of these strains to develop normally under nonpremissive conditions suggested that flagellin synthesis and stalk formation are dependent on the completion of different cell-cycle steps: the periodicity of flagellin synthesis is achieved by coupling it to either DNA chain elongation or completion, and stalk formation is dependent on a later step in the cell-division pathway. These developmental events are not themselves required for cell division, however.
Proceedings of the National Academy of Sciences of the United States of America © 1977 National Academy of Sciences