Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Addition of Colchicine-Tubulin Complex to Microtubule Ends: The Mechanism of Substoichiometric Colchicine Poisoning

Robert L. Margolis and Leslie Wilson
Proceedings of the National Academy of Sciences of the United States of America
Vol. 74, No. 8 (Aug., 1977), pp. 3466-3470
Stable URL: http://www.jstor.org/stable/66962
Page Count: 5
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Addition of Colchicine-Tubulin Complex to Microtubule Ends: The Mechanism of Substoichiometric Colchicine Poisoning
Preview not available

Abstract

Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin complex.

Page Thumbnails

  • Thumbnail: Page 
3466
    3466
  • Thumbnail: Page 
3467
    3467
  • Thumbnail: Page 
3468
    3468
  • Thumbnail: Page 
3469
    3469
  • Thumbnail: Page 
3470
    3470