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Journal Article

Addition of Colchicine-Tubulin Complex to Microtubule Ends: The Mechanism of Substoichiometric Colchicine Poisoning

Robert L. Margolis and Leslie Wilson
Proceedings of the National Academy of Sciences of the United States of America
Vol. 74, No. 8 (Aug., 1977), pp. 3466-3470
Stable URL: http://www.jstor.org/stable/66962
Page Count: 5

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Topics: Microtubules, Dimers, Poisoning, Polymerization, Beef, Incubation, Poisons, Depolymerization, Cells, Embryos
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Addition of Colchicine-Tubulin Complex to Microtubule Ends: The Mechanism of Substoichiometric Colchicine Poisoning
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Abstract

Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin complex.

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