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Biological Properties of Poliovirus Encapsulated in Lipid Vesicles: Antibody Resistance and Infectivity in Virus-Resistant Cells
Tazewell Wilson, Demetrios Papahadjopoulos and Robert Taber
Proceedings of the National Academy of Sciences of the United States of America
Vol. 74, No. 8 (Aug., 1977), pp. 3471-3475
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/66963
Page Count: 5
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We present evidence that poliovirus can be encapsulated in synthetic large phospholipid vesicles. The virus associated with the vesicles is found to be (i) resistant to anti-serum against poliovirus and (ii) infectious for cells that are normally resistant to virus infection because of a membrane restriction. Our interpretation of these results is that the virus is entrapped in the interior aqueous space of the vesicles and that this vesicle-associated virus is introduced directly into the cytoplasm of the cells via fusion of the vesicles with the cellular plasma membrane, bypassing the surface receptor-mediated restriction.
Proceedings of the National Academy of Sciences of the United States of America © 1977 National Academy of Sciences