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Theoretical Study of Genetic Variability, Assuming Stepwise Production of Neutral and very Slightly Deleterious Mutations

Takeo Maruyama and Motoo Kimura
Proceedings of the National Academy of Sciences of the United States of America
Vol. 75, No. 2 (Feb., 1978), pp. 919-922
Stable URL: http://www.jstor.org/stable/67899
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Theoretical Study of Genetic Variability, Assuming Stepwise Production of Neutral and very Slightly Deleterious Mutations
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Abstract

Mathematical treatments are presented that enable us to compute the amount of genetic variability maintained in a finite population, assuming that mutations occur in stepwise fashion and that both selectively neutral and slightly deleterious alleles are involved. Two numerical examples show that, if very slightly deleterious mutations are prevalent, the amount of genetic variability increases much more slowly as the population number increases than is the case when all the mutations are strictly neutral.

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