Access

You are not currently logged in.

Access JSTOR through your library or other institution:

login

Log in through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Journal Article

Beneficial and Detrimental Actions of Histamine H1- and H2-Receptor Antagonists in Circulatory Shock

Burton M. Altura and Simon Halevy
Proceedings of the National Academy of Sciences of the United States of America
Vol. 75, No. 6 (Jun., 1978), pp. 2941-2944
Stable URL: http://www.jstor.org/stable/68361
Page Count: 4
  • Read Online (Free)
  • Subscribe ($19.50)
  • Add to My Lists
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Beneficial and Detrimental Actions of Histamine H1- and H2-Receptor Antagonists in Circulatory Shock
Preview not available

Abstract

This study explores the use of both histamine H1- and H2-receptor antagonists in two different forms of circulatory shock and suggests that histamine may be involved in more than one way in the pathophysiology of circulatory shock. Various single doses of diphenhydramine, chlorpheniramine, promethazine, and burimamide were administered intravenously to Wistar rats subjected to hemorrhagic or bowel ischemia shock. Cumulative survival and mortality, as well as arterial blood pressures and microhematocrits, were monitored. Pretreatment of the animals with the three different H1-receptor antagonists exerted significant protection against both forms of shock. Rats pretreated with the H2-receptor antagonist, burimamide, demonstrated an exacerbated mortality after induction of shock. Animals pretreated with H1-receptor antagonists showed significantly higher mean arterial blood pressure, greater compensatory rebound of blood pressure after induction of shock, and greater responses to transfusion after hemorrhage than control, shocked animals. Similarly, rats pretreated with the H1-receptor blockers demonstrated significantly greater compensatory hemodilution which continued late in shock. In marked contrast, rats pretreated with burimamide exhibited opposite effects after hemorrhage and bowel ischemia, i.e., significant falls in blood pressure, lack of compensatory rebound and response to transfusion of shed blood, and a progressive hemoconcentration. This report clearly demonstrates beneficial actions of histamine H1-receptor antagonists and detrimental effects of H2-receptor antagonists on survival and other parameters in these forms of circulatory shock.

Page Thumbnails

  • Thumbnail: Page 
2941
    2941
  • Thumbnail: Page 
2942
    2942
  • Thumbnail: Page 
2943
    2943
  • Thumbnail: Page 
2944
    2944