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Beneficial and Detrimental Actions of Histamine H1- and H2-Receptor Antagonists in Circulatory Shock
Burton M. Altura and Simon Halevy
Proceedings of the National Academy of Sciences of the United States of America
Vol. 75, No. 6 (Jun., 1978), pp. 2941-2944
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/68361
Page Count: 4
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This study explores the use of both histamine H1- and H2-receptor antagonists in two different forms of circulatory shock and suggests that histamine may be involved in more than one way in the pathophysiology of circulatory shock. Various single doses of diphenhydramine, chlorpheniramine, promethazine, and burimamide were administered intravenously to Wistar rats subjected to hemorrhagic or bowel ischemia shock. Cumulative survival and mortality, as well as arterial blood pressures and microhematocrits, were monitored. Pretreatment of the animals with the three different H1-receptor antagonists exerted significant protection against both forms of shock. Rats pretreated with the H2-receptor antagonist, burimamide, demonstrated an exacerbated mortality after induction of shock. Animals pretreated with H1-receptor antagonists showed significantly higher mean arterial blood pressure, greater compensatory rebound of blood pressure after induction of shock, and greater responses to transfusion after hemorrhage than control, shocked animals. Similarly, rats pretreated with the H1-receptor blockers demonstrated significantly greater compensatory hemodilution which continued late in shock. In marked contrast, rats pretreated with burimamide exhibited opposite effects after hemorrhage and bowel ischemia, i.e., significant falls in blood pressure, lack of compensatory rebound and response to transfusion of shed blood, and a progressive hemoconcentration. This report clearly demonstrates beneficial actions of histamine H1-receptor antagonists and detrimental effects of H2-receptor antagonists on survival and other parameters in these forms of circulatory shock.
Proceedings of the National Academy of Sciences of the United States of America © 1978 National Academy of Sciences