Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

A Factor from Neurons Increases the Number of Acetylcholine Receptor Aggregates on Cultured Muscle Cells

C. N. Christian, M. P. Daniels, H. Sugiyama, Z. Vogel, L. Jacques and P. G. Nelson
Proceedings of the National Academy of Sciences of the United States of America
Vol. 75, No. 8 (Aug., 1978), pp. 4011-4015
Stable URL: http://www.jstor.org/stable/68816
Page Count: 5
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
A Factor from Neurons Increases the Number of Acetylcholine Receptor Aggregates on Cultured Muscle Cells
Preview not available

Abstract

There is an increase in the number of acetylcholine (AcCho) receptor aggregates on striated embryonic mouse myotubes when they are cocultured with clonal neuroblastoma-glioma hybrid cells. Medium conditioned by hybrid cells contains a factor which increases the number of AcCho receptor aggregates on myotubes cultured from mouse, rat or chick muscle. AcCho receptor-aggregating activity was present in medium conditioned by the neuroblastoma parent clone but was not detected in medium conditioned by cells of the parent glioma clone, fibroblasts, or HeLa cells. The factor increased the aggregation of AcCho receptors within 24 hr without a significant increase in the total number of AcCho receptors, and its action did not depend on myotube protein synthesis. The factor appears to rearrange the distribution of myotube AcCho receptors either by aggregating mobile AcCho receptors or by stabilizing labile receptor aggregates.

Page Thumbnails

  • Thumbnail: Page 
4011
    4011
  • Thumbnail: Page 
4012
    4012
  • Thumbnail: Page 
4013
    4013
  • Thumbnail: Page 
4014
    4014
  • Thumbnail: Page 
4015
    4015