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H-2 Complementation in Anti-H-Y Cytotoxic T-Cell Responses can Occur in Chimeric Mice

Takeshi Matsunaga and Elizabeth Simpson
Proceedings of the National Academy of Sciences of the United States of America
Vol. 75, No. 12 (Dec., 1978), pp. 6207-6210
Stable URL: http://www.jstor.org/stable/68930
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
H-2 Complementation in Anti-H-Y Cytotoxic T-Cell Responses can Occur in Chimeric Mice
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Abstract

Cytotoxic T-cell responses against the H-Y antigen in mice are under the control of major histocompatibility complex genes. Not only must cytotoxic T cells recognize both H-Y antigens and ``self'' H-2K/D molecules to lyse male target cells, but also ``appropriate association'' between H-Y antigens and H-2K/D antigens is required to induce such cytotoxic responses. Furthermore, it is suggested that appropriate association with H-2-I antigens may also be required to generate H-Y specific helper cells for the cytotoxic response. BALB/c(KdIdDd) mice are nonresponders against syngeneic H-Y antigens, because they lack appropriate associative H-2K/D antigens. This results in the failure of generation of anti H-Y cytotoxic cells, although helper cells may be induced. F1 hybrid mice (BALB/c × C3H/He)F1 or H-2 recombinant mice C3H· OH(KdIdDk) are responders, because H-2Dk (and H-2Kk in the F1) molecules offer appropriate association to H-Y antigens. We here report that allophenic chimeras (H-2$^{d}\leftrightarrow $ H-2k) and irradiation bone marrow chimeras [H-2d + H-2k→ F1(H-2d× H-2k)] generate anti-H-Y cytotoxic responses but that cells of the BALB/c(H-2d) genotype comprise most if not all of the cytotoxic cells. A working model is proposed to account for major histocompatibility complex control over anti-H-Y cytotoxic T-cell responses.

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