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Influence of Major Histocompatibility Haplotype on Autoimmune Disease Varies in Different Inbred Families of Chickens
Larry D. Bacon and Noel R. Rose
Proceedings of the National Academy of Sciences of the United States of America
Vol. 76, No. 3 (Mar., 1979), pp. 1435-1437
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/69300
Page Count: 3
You can always find the topics here!Topics: Haplotypes, Autoimmune diseases, Inbreeding, Genetic loci, Chickens, Inbred strains, Genetics, Antibodies, Juveniles, Autoimmune thyroiditis
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Three partially inbred substrains of Obese strain chickens were studied for the spontaneous development of autoimmune thyroiditis. The influence of the major histo-compatibility complex (B haplotype) was marked in one, less marked but still significant in a second, and barely detectable and transient in a third substrain. These differences in the effect of B haplotype may be due to the overriding action of genes other than those within the B haplotype.
Proceedings of the National Academy of Sciences of the United States of America © 1979 National Academy of Sciences