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Influence of Major Histocompatibility Haplotype on Autoimmune Disease Varies in Different Inbred Families of Chickens

Larry D. Bacon and Noel R. Rose
Proceedings of the National Academy of Sciences of the United States of America
Vol. 76, No. 3 (Mar., 1979), pp. 1435-1437
Stable URL: http://www.jstor.org/stable/69300
Page Count: 3
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Influence of Major Histocompatibility Haplotype on Autoimmune Disease Varies in Different Inbred Families of Chickens
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Abstract

Three partially inbred substrains of Obese strain chickens were studied for the spontaneous development of autoimmune thyroiditis. The influence of the major histo-compatibility complex (B haplotype) was marked in one, less marked but still significant in a second, and barely detectable and transient in a third substrain. These differences in the effect of B haplotype may be due to the overriding action of genes other than those within the B haplotype.

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