You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
$\beta $-Endorphin: Analgesic and Hormonal Effects in Humans
Kathleen M. Foley, Ione A. Kourides, Charles E. Inturrisi, Robert F. Kaiko, Charles G. Zaroulis, Jerome B. Posner, Raymond W. Houde and Choh Hao Li
Proceedings of the National Academy of Sciences of the United States of America
Vol. 76, No. 10 (Oct., 1979), pp. 5377-5381
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/70454
Page Count: 5
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
The pharmacokinetics and the hormonal, analgesic, and behavioral effects of several doses of human $\beta $-endorphin were evaluated after intravenous administration to three patients and intracerebroventricular administration to one patient with pain caused by cancer. These effects were compared to the hormonal effects of intravenously administered morphine sulfate in two patients and an enkephalin analog in two baboons. The mean terminal half-life after intravenous administration of 5 or 10 mg of human $\beta $-endorphin to three patients was 37 min; the mean volume of distribution was 178 ml/kg, and the metabolic clearance rate was 3.2 (ml/min)/kg. The half-life of $\beta $-endorphin in cerebrospinal fluid after intracerebroventricular administration was 93 min, and the volume of distribution was 0.74 ml/kg. A rapid rise in plasma prolactin followed both intravenous and intracerebroventricular $\beta $-endorphin. Intravenous administration did not affect plasma growth hormone, but intracerebroventricular administration suppressed plasma growth hormone. No significant change in plasma growth hormone was noted after intravenous administration of morphine to humans, but plasma growth hormone decreased in one baboon after administration of the enkephalin analog. $\beta $-Endorphin-stimulated release of prolactin occurred at doses lower than those required to produce analgesic and other behavioral effects. When both hormonal and analgesic effects were observed (after 7.5 mg were given intracerebroventricularly), the onset of the hormonal response slightly preceded the analgesic and behavioral responses. These studies suggest that the hormonal effects of $\beta $-endorphin are species dependent and are similar to those of morphine. Hormonal and analgesic effects of $\beta $-endorphin appear to result from the activation of opiate receptors that differ in their locations and characteristics.
Proceedings of the National Academy of Sciences of the United States of America © 1979 National Academy of Sciences