Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Acute Muscle Denervation Induced by β -Bungarotoxin

T. Abe, A. R. Limbrick and R. Miledi
Proceedings of the Royal Society of London. Series B, Biological Sciences
Vol. 194, No. 1117 (Nov. 12, 1976), pp. 545-553
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/77144
Page Count: 11
  • Read Online (Free)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Acute Muscle Denervation Induced by β -Bungarotoxin
Preview not available

Abstract

The neurotoxin, β -bungarotoxin (β -BuTX) purified from Bungarus multicinctus snake venom exerts various effects on frog and rat motor nerve terminals. Exposure to β -BuTX triggers, in the terminals, impulses which are rapidly distributed to the whole motor unit and elicit contractions of the muscle. β -BuTX raises the frequency of spontaneous release of acetylcholine quanta and inhibits the release evoked by nerve impulses, all of which leads to complete cessation of transmitter release. Subsequently, the motor axon disappears from the endplate and the Schwann cell establishes extensive synaptic contact with the muscle fibre. After only 30 min in β -BuTX, some endplates attain a stage of denervation similar to that seen several days after transecting the motor nerve. The neuromuscular effects of β -BuTX may result from its phospholipase activity and from an increase in the level of ionized calcium inside the terminals.

Page Thumbnails

  • Thumbnail: Page 
545
    545
  • Thumbnail: Page 
546
    546
  • Thumbnail: Page 
547
    547
  • Thumbnail: Page 
548
    548
  • Thumbnail: Page 
549
    549
  • Thumbnail: Page 
550
    550
  • Thumbnail: Page 
[unnumbered]
    [unnumbered]
  • Thumbnail: Page 
[unnumbered]
    [unnumbered]
  • Thumbnail: Page 
551
    551
  • Thumbnail: Page 
552
    552
  • Thumbnail: Page 
553
    553