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Formylmethionyl-tRNA Alters RNA Polymerase Specificity
Paul G. Debenham, Olaf Pongs and Andrew A. Travers
Proceedings of the National Academy of Sciences of the United States of America
Vol. 77, No. 2, [Part 2: Biological Sciences] (Feb., 1980), pp. 870-874
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/8340
Page Count: 5
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Escherichia coli fMet-tRNAf Met alters the pattern of promoter selection of E. coli RNA polymerase (RNA nucleotidyltransferase, nucleosidetriphosphate:RNA nucleotidyltransferase; EC 18.104.22.168), affecting RNA synthesis from the rRNA, suIII + tRNA, and lac promoters in different ways. The in vitro synthesis of the stable RNA species is selectively decreased, whereas that of lac RNA from both the wild-type and mutant UV5 promoters is selectively increased at high ionic strength. The functional effect of fMet-tRNAf Met resembles that of the nucleotide guanosine 3′-diphosphate 5′-diphosphate (ppGpp). This nucleotide competes with the binding of fMet-tRNAf Met to RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America © 1980 National Academy of Sciences