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Target Selectivity of Interferon-Induced Human Killer Lymphocytes Related to their Fc Receptor Expression
Maria G. Masucci, Giuseppe Masucci, Eva Klein and Wolfgang Berthold
Proceedings of the National Academy of Sciences of the United States of America
Vol. 77, No. 6, [Part 2: Biological Sciences] (Jun., 1980), pp. 3620-3624
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/8942
Page Count: 5
You can always find the topics here!Topics: Lymphocytes, Interferons, Cell lines, Cytotoxicity, T lymphocytes, Erythrocytes, Receptors, Dose response relationship, Dextrans, Fc receptors
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Human blood lymphocytes were fractionated on the basis of surface characteristics such as adherence to nylon wool and expression of erythrocyte (E) and Fc receptors. The various subsets were incubated with interferon for 3 hr. Two cell lines that differ in sensitivity to the natural killer effect, K562 and Daudi, were exposed to these lymphocytes (i.e., their sensitivity to interferon-activated killing was tested). Cell line Daudi, with a low sensitivity to the natural killer effect, was also affected by interferon-activated killing. The efficiency of the nonadherent subsets, separated according to the expression of E receptor, ranked similarly in natural killing (anti-K562) and interferon-activated killing (anti-K562 and anti-Daudi) in the following order: E receptor-negative cells, low-affinity E receptor-positive cells, and high-affinity E receptor-positive cells. Further separation on the basis of Fc receptor expression revealed a difference between the two targets. The Fc receptor-positive and -negative cells that did not express high-affinity E receptors killed K562 with similar efficiency whereas Daudi cells were more sensitive to the effect of cells devoid of Fc receptor. Results obtained with other targets suggested that T cell lines behave similarly to K562 and that the difference may be generally valid for T and B cell lines.
Proceedings of the National Academy of Sciences of the United States of America © 1980 National Academy of Sciences