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Passive Immunotherapy Prevents Expression of Endogenous Moloney Virus and Amplification of Proviral DNA in BALB/Mo Mice
Peter Nobis and Rudolf Jaenisch
Proceedings of the National Academy of Sciences of the United States of America
Vol. 77, No. 6, [Part 2: Biological Sciences] (Jun., 1980), pp. 3677-3681
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/8954
Page Count: 5
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BALB/Mo mice carrying the Moloney murine leukemia virus (M-MuLV) as an endogenous virus become viremic soon after birth and develop leukemia at a later age. M-MuLV-specific gene expression and an increase of virus-specific DNA copies in lymphatic target organs are characteristics of the preleukemic phase. Passive immunotherapy of newborn BALB/Mo mice with anti-gp70 glycoprotein or anti-M-MuLV serum prevented viremia and delayed significantly the subsequent development of leukemia. Molecular hybridization experiments showed that both virus-specific genome transcription and virus-specific DNA amplification could be completely suppressed by antiserum treatment. Thus virus-specific RNA concentrations in target organs of immunized BALB/Mo mice of 6 months or older were as low as in normal BALB/c mice. This is an age at which untreated BALB/Mo mice have already developed malignant lymphoma. Our experiments demonstrate that treatment with antiserum interferes with the early events of virus expression and thus prevents the subsequent steps leading to leukemia.
Proceedings of the National Academy of Sciences of the United States of America © 1980 National Academy of Sciences