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Peptide Inhibitor of Morphine- and β -Endorphin-Induced Analgesia

Nancy M. Lee, Howard J. Friedman, Leonid Leybin, Tae Mook Cho, Horace H. Loh and Choh Hao Li
Proceedings of the National Academy of Sciences of the United States of America
Vol. 77, No. 9, [Part 2: Biological Sciences] (Sep., 1980), pp. 5525-5526
Stable URL: http://www.jstor.org/stable/9367
Page Count: 2
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Abstract

The synthetic β -endorphin analogs with the omission of the NH2-terminal [Met]enkephalin segment [β -endorphin-(6-31) and β -endorphin-(20-31)] are shown to inhibit morphine- or β -endorphin-induced analgesia in mice by the tail-flick test, whereas the synthetic NH2-terminal pentadecapeptide β -endorphin-(1-15) has no inhibitory activity. This study raises the possibility that endogenous inhibiting peptides exist in the brain which play a role in the regulation of endorphin actions.

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