Founded in 1967, the Leonard Davis Institute of Health Economics at the University of Pennsylvania (Penn LDI) has been the leading university institute dedicated to data-driven, policy-focused research that improves our nation’s health and health care. As Penn’s hub for research on population health, the health care system, and health policy, Penn LDI supports, connects, engages, and amplifies interdisciplinary research of over 300 Senior Fellows from all of Penn’s schools, the University of Pennsylvania Health System, and the Children’s Hospital of Philadelphia. Penn LDI’s five priority areas highlight some of the most pressing challenges facing our nation’s health system today: (1) health care access and coverage; (2) health equity; (3) improving care for older adults; (4) opioid epidemic; and (5) population health. Penn LDI trains the next generation of health services and health policy researchers through a resource-rich environment and innovative educational programs at the undergraduate, masters, doctoral, and postdoctoral levels. The institute’s role as an active convener at Penn is augmented by a dynamic research and policy seminar series, conferences, and a growing number of research partnerships with academic and service organizations regionally and nationally.