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Protection against Marek's Disease by Vaccination with a Herpesvirus of Turkeys
William Okazaki, H. G. Purchase and B. R. Burmester
Vol. 14, No. 2 (May, 1970), pp. 413-429
Published by: American Association of Avian Pathologists
Stable URL: http://www.jstor.org/stable/1588488
Page Count: 17
You can always find the topics here!Topics: Viruses, Antibodies, Viral diseases, Lesions, Vaccination, Gallid herpesvirus 2, Experimentation, Herpesviridae, Cell culture techniques, Antigens
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Studies were conducted to determine whether a herpesvirus isolated from turkeys (HVT) would protect chickens against subsequent challenge with the virulent JM strain of Marek's disease herpesvirus (MDHV). HVT administered intra-abdominally at doses as low as 600 plaque-forming units per one-day-old chick gave protection against Marek's disease (MD). The virus would protect when birds were challenged with MDHV by intra-abdominal inoculation at 3 weeks or by contact exposure as early as 2 weeks postvaccination. Chickens inoculated with HVT and observed for 17 to 20 weeks did not develop lesions. Birds produced antibody and infection persisted throughout this period, however, as indicated by reisolation of the virus. Furthermore, HVT did not spread to chickens in direct contact with vaccinated birds. Thus HVT gives substantial protection against the development of MD yet is nonpathogenic and noncontagious, all of which are important characteristics of vaccine viruses.
Avian Diseases © 1970 American Association of Avian Pathologists