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Ceruloplasmin, a Copper-Transport Protein, Can Act as a Growth Promoter for Some Cell Lines in Serum-Free Medium
J. P. Mather
Vol. 18, No. 12 (Dec., 1982), pp. 990-996
Published by: Society for In Vitro Biology
Stable URL: http://www.jstor.org/stable/20170553
Page Count: 7
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Ceruloplasmin (Cp) is a copper-transport protein with ferric oxidase activity found in high concentrations in the plasma of all vertebrates. Five cell lines (TR-1, TR-M, TR-ST, TM₃, and TM₄) derived from the testis can be grown in hormone-supplemented serum-free medium. Cp stimulates the growth of four of these five cell lines in serum-free medium. The growth stimulation by Cp is not affected by the addition or deletion of free copper, nor does copper itself elicit any significant growth response. Cp can stimulate growth also in the absence of TF suggesting that it is not acting solely to promote Fe(III)-TF binding. A strong interaction is seen between Cp and high density lipoprotein (HDL), with the presence of either decreasing the growth-promoting activity of the other. It is suggested that these cell lines may provide an ideal system for studying the action of Cp at the cellular level.
In Vitro © 1982 Society for In Vitro Biology