1. A review of the literature shows that in nearly all cases tropical rain forest fragmentation has led to a local loss of species. Isolated fragments suffer reductions in species richness with time after excision from continuous forest, and small fragments often have fewer species recorded for the same effort of observation than large fragments or areas of continuous forest. 2. Birds have been the most frequently studied taxonomic group with respect to the effects of tropical forest fragmentation. 3. The mechanisms of fragmentation-related extinction include the deleterious effects of human disturbance during and after deforestation, the reduction of population sizes, the reduction of immigration rates, forest edge effects, changes in community structure (second- and higher-order effects) and the immigration of exotic species. 4. The relative importance of these mechanisms remains obscure. 5. Animals that are large, sparsely or patchily distributed, or very specialized and intolerant of the vegetation surrounding fragments, are particularly prone to local extinction. 6. The large number of indigenous species that are very sparsely distributed and intolerant of conditions outside the forest make evergreen tropical rain forest particularly susceptible to species loss through fragmentation. 7. Much more research is needed to study what is probably the major threat to global biodiversity.
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