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Role of Interferon-γ in Experimental Gram-Negative Sepsis

Ayona T. Silva and Jonathan Cohen
The Journal of Infectious Diseases
Vol. 166, No. 2 (Aug., 1992), pp. 331-335
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30112932
Page Count: 5
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Role of Interferon-γ in Experimental Gram-Negative Sepsis
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Abstract

To study the role of interferon-γ (IFN-γ) in gram-negative shock, mortality was compared in mice receiving either a monoclonal antibody to IFN-γ (H22) or an irrelevant monoclonal antibody (L2-3D9) before or after an $LD_90$ dose of Escherichia coli O111:B4. H22 given either 1 h before or 0.5 h after bacterial challenge protected mice from death (mortality at 48 h, 28% vs. 83%, P < .001). Serum tumor necrosis factor-α (TNFα) levels and bacterial counts in blood and organs (liver, spleen, heart, and brain) were similar in H22-treated animals and controls. The peak serum TNFα levels were 95.7 ± 16.4 ng/mL and 80.7 ± 14.9 ng/mL in the H22 and control groups, respectively. These results indicate that IFN-γ plays a significant role in the pathogenesis of gram-negative sepsis.

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