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Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor on Granulocyte Recovery and Candida Albicans Infection in Granulocytopenic Mice

Sigurd Steinshamn, Kåre Bergh and Anders Waage
The Journal of Infectious Diseases
Vol. 168, No. 6 (Dec., 1993), pp. 1444-1448
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30113695
Page Count: 5
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Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor on Granulocyte Recovery and Candida Albicans Infection in Granulocytopenic Mice
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Abstract

The combined action of stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) on granulocyte recovery and infection with Candida albicans was studied. In mice rendered granulocytopenic with 200 mg/kg cyclophosphamide, daily coinjection of SCF (100 Mg/kg) and G-CSF (10 Mg/kg) for 5 days synergistically stimulated granulocyte recovery compared with either factor alone. Growth of C albicans in the kidneys of granulocytopenic mice with experimental C. albicans infection was reduced by the combined regimen to 250Zo of that in vehicle-treated controls (P = .018), whereas either factor administered alone in the same doses had no effect. The combined regimen also significantly protected against lethal infection with C. albicans (P < .01). Either factor administered alone in the same doses had no effect on lethality compared with vehicle-treated controls. The combination of SCF and G-CSF may be useful in the treatment of infections with C albicans in the granulocytopenic host.

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