Brugia pahangi infections of jirds (Meriones unguiculatus) produce a granulomatous inflammatory response within the lymphatic vessels. Granulomas that form around beads coated with soluble adult antigens embolized in the lungs have been used to measure this response. Similar lesions were observed in naive jirds receiving lymph node cells and splenocytes from animals with acute infections. This was not the case with cells from chronically infected jirds that were hyporesponsive to implanted antigen-coated beads. Passively transferred immune sera collected during the acute and chronic periods of infection did not transfer this response. Lymph node cells but not splenocytes obtained from chronically infected jirds induced a down regulation of this response in animals during the acute period. These results indicate that this inflammatory response in the jird is cell mediated and that adoptive transfer in jirds is feasible. The induction of the down-regulated state may also be mediated by cells, but not serum factors.
The Journal of Parasitology is the official publication of the American Society of Parasitologists (ASP). It has been in print continuously since 1914, when it was founded by Henry Baldwin Ward. The journal focuses on general parasitology, as well as parasites of medical, veterinary, and economic importance. Most of the emphasis rests with eukaryotic parasites, although vectors for prokaryotic organisms and viruses are also included. The journal is printed at Allen Press in Lawrence, Kansas, in six issues per year. Institutional subscriptions are available. Membership in ASP includes receipt of the Journal of Parasitology, a quarterly Newsletter, and abstracts for the annual meetings; students can join at a much reduced rate. The journal is online via BioOne. The editor of the journal is Dr. Michael V.K. Sukhdeo. For further information regarding publication in the journal, contact the editorial office at journalofparasitology@gmail.com. For information about membership in ASP, contact the society:, http://amsocparasit.org/. For subscription information, contact asp@allenpress.com.
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The Journal of Parasitology
© 1997 The American Society of Parasitologists