Interaction, defined as departure of disease rates from an additive model, can be measured by the relative excess risk due to interaction, or the attributable proportion due to interaction. Point estimates can be obtained using multiple logistic regression. Using simulated case-control data, we compare several confidence interval estimation techniques for these measures. These include a symmetrical interval based on the delta method estimate of the variance, and three types of bootstrap confidence intervals. One such bootstrap method has coverage closest to the nominal level and is the most evenly balanced with respect to the direction in which intervals miss the true value. The estimation methods are applied to data from an actual case-control study, and the results are interpreted in light of the simulation study.
Epidemiology is a peer-reviewed scientific journal that publishes original research on the full spectrum of epidemiologic topics. Journal content ranges from cancer, heart disease and other chronic illnesses to reproductive, environmental, psychosocial, infectious-disease and genetic epidemiology. The journal places special emphasis on theory and methodology, and welcomes commentaries that explore fundamental assumptions or offer provocative dissent.
Wolters Kluwer Health is a leading provider of information for professionals and students in medicine, nursing, allied health, pharmacy and the pharmaceutical industry. Major brands include traditional publishers of medical and drug reference tools and textbooks, such as Lippincott Williams & Wilkins and Facts & Comparisons; electronic information providers, such as Ovid Technologies, Medi-Span and ProVation Medical; and pharmaceutical information providers Adis International and Source®. Wolters Kluwer Health is a division of Wolters Kluwer, a leading multi-national publisher and information services company with annual revenues (2005) of €3.4 billion and approximately 18,400 employees worldwide. Wolters Kluwer is headquartered in Amsterdam, the Netherlands. Its depositary receipts of shares are quoted on the Euronext Amsterdam (WKL) and are included in the AEX and Euronext 100 indices.
This item is part of a JSTOR Collection.
For terms and use, please refer to our
Epidemiology
© 1996 Lippincott Williams & Wilkins